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ea0056p387 | Diabetes (to include epidemiology, pathophysiology) | ECE2018

The effect of the dopamine agonist cabergoline on insulin sensitivity in the skeletal muscle: an in vitro study in a mouse cell model demonstrating mediation by serotoninergic receptors

Negri Mariarosaria , Pivonello Claudia , Gennaro Gilda Di , Angelis Cristina de , Simeoli Chiara , Iacuaniello Davide , Nettore Immacolata Cristina , Macchia Paolo Emidio , Muscogiuri Giovanna , Colao Annamaria , Pivonello Rosario

Insulin resistance (IR), characterized by an impairment of target tissues to insulin responsiveness, is the core defect preceding diabetes. Preclinical and clinical data have suggested a role for the dopaminergic system in glucose homeostasis control. The aim of the current study was to investigate the role of the dopamine agonist cabergoline (CAB), displaying high affinity for dopamine type 2 (DR2) receptor and low affinity for serotonin receptors (5-HTRs), in the regulation ...

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Endocrine Abstracts

The effect of the dopamine agonist cabergoline on insulin sensitivity in the skeletal muscle: an in vitro study in a mouse cell model demonstrating mediation by serotoninergic receptors

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